P42262.3
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UniProt Primary Accession #
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NCBI Official Full Name
Glutamate receptor 2
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, AMPA 2
NCBI Official Synonym Symbols
GLUR2; GLURB; GluA2; HBGR2; GluR-K2 [Similar Products]
NCBI Protein Information
glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2
UniProt Protein Name
Glutamate receptor 2
UniProt Synonym Protein Names
AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2
UniProt Synonym Gene Names
UniProt Entry Name
GRIA2_HUMAN
NCBI Summary for GRIA2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIA2
GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; plasma membrane; cell junction
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; signal transduction
Research Articles on GRIA2
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Products associated with anti-GRIA2 antibody
Pathways associated with anti-GRIA2 antibody
Diseases associated with anti-GRIA2 antibody
Organs/Tissues associated with anti-GRIA2 antibody
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