NP_795932.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hypoxia-inducible factor 1-alpha inhibitor
NCBI Official Synonym Full Names
hypoxia-inducible factor 1, alpha subunit inhibitor
NCBI Official Synonym Symbols
FIH1; 2310046M24Rik; A830014H24Rik [Similar Products]
NCBI Protein Information
hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase
UniProt Protein Name
Hypoxia-inducible factor 1-alpha inhibitor
UniProt Synonym Protein Names
Hypoxia-inducible factor asparagine hydroxylase
UniProt Entry Name
HIF1N_MOUSE
UniProt Comments for Hif1an
HIF1AN: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4.
Protein type: Oxidoreductase; EC 1.14.11.30; EC 1.14.11.n4
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: NF-kappaB binding; protein homodimerization activity; zinc ion binding; dioxygenase activity; carboxylic acid binding; iron ion binding; metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity; cofactor binding; Notch binding
Biological Process: peptidyl-aspartic acid hydroxylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; peptidyl-asparagine hydroxylation; negative regulation of Notch signaling pathway; positive regulation of myoblast differentiation
Research Articles on Hif1an
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Pathways associated with anti-Hif1an antibody
Diseases associated with anti-Hif1an antibody
Organs/Tissues associated with anti-Hif1an antibody
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