NP_073187
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,666 Da
NCBI Official Full Name
heart- and neural crest derivatives-expressed protein 2
NCBI Official Synonym Full Names
heart and neural crest derivatives expressed 2
NCBI Protein Information
heart- and neural crest derivatives-expressed protein 2
UniProt Protein Name
Heart- and neural crest derivatives-expressed protein 2
UniProt Synonym Protein Names
Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND
UniProt Synonym Gene Names
UniProt Entry Name
HAND2_RAT
NCBI Summary for HAND2
acts in complex with Gata4 to activate transcription of cardiac specific genes [RGD, Feb 2006]
UniProt Comments for HAND2
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' ().
Research Articles on HAND2
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Products associated with anti-HAND2 antibody
Diseases associated with anti-HAND2 antibody
Organs/Tissues associated with anti-HAND2 antibody
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