NP_071330.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,910 Da
NCBI Official Full Name
differentially expressed in FDCP 6 homolog
NCBI Official Synonym Full Names
DEF6, guanine nucleotide exchange factor
NCBI Protein Information
differentially expressed in FDCP 6 homolog
UniProt Protein Name
Differentially expressed in FDCP 6 homolog
UniProt Synonym Protein Names
IRF4-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
DEFI6_HUMAN
NCBI Summary for DEF6
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
UniProt Comments for DEF6
DEF6: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
Protein type: GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 6p21.33-p21.1
Cellular Component: cytoskeleton; filopodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding
Research Articles on DEF6
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Pathways associated with anti-DEF6 antibody
Diseases associated with anti-DEF6 antibody
Organs/Tissues associated with anti-DEF6 antibody
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