P46940.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ras GTPase-activating-like protein IQGAP1
NCBI Official Synonym Full Names
IQ motif containing GTPase activating protein 1
NCBI Protein Information
ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs
UniProt Protein Name
Ras GTPase-activating-like protein IQGAP1
UniProt Synonym Protein Names
p195
UniProt Synonym Gene Names
UniProt Entry Name
IQGA1_HUMAN
NCBI Summary for IQGAP1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
UniProt Comments for IQGAP1
IQGAP1: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Protein type: GAPs, Ras; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: microtubule; neuron projection; focal adhesion; leading edge; actin filament; actin cytoskeleton; nucleoplasm; microtubule cytoskeleton; extrinsic to internal side of plasma membrane; growth cone; axon; cytoplasm; plasma membrane; midbody; cell junction; lateral plasma membrane
Molecular Function: calmodulin binding; protein serine/threonine kinase activator activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein complex binding; Rac GTPase binding; calcium ion binding; protein phosphatase binding; protein kinase binding; GTPase activator activity; GTPase inhibitor activity
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of protein kinase activity; negative regulation of dephosphorylation; small GTPase mediated signal transduction; negative regulation of catalytic activity; energy reserve metabolic process; platelet-derived growth factor receptor signaling pathway; signal transduction; regulation of insulin secretion; regulation of cytokine production; positive regulation of GTPase activity
Research Articles on IQGAP1
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Products associated with anti-IQGAP1 antibody
Pathways associated with anti-IQGAP1 antibody
Diseases associated with anti-IQGAP1 antibody
Organs/Tissues associated with anti-IQGAP1 antibody
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