NP_003629.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
integrin alpha-8
NCBI Official Synonym Full Names
integrin, alpha 8
NCBI Protein Information
integrin alpha-8
UniProt Protein Name
Integrin alpha-8
UniProt Entry Name
ITA8_HUMAN
NCBI Summary for ITGA8
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
UniProt Comments for ITGA8
ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 10p13
Cellular Component: cell surface; focal adhesion; apical part of cell; endoplasmic reticulum; postsynaptic density; plasma membrane; perikaryon; integrin complex
Molecular Function: metal ion binding
Biological Process: integrin-mediated signaling pathway; smooth muscle development; extracellular matrix organization and biogenesis; inner ear morphogenesis; cell-cell adhesion; establishment of protein localization; cell projection organization and biogenesis; cell-matrix adhesion; positive regulation of transforming growth factor beta receptor signaling pathway; mesodermal cell differentiation; brain development; kidney development; metanephros development; memory
Disease: Renal Hypodysplasia/aplasia 1
Product References and Citations for anti-ITGA8 antibody
Benoit, Y.D., et al. Biochem. Biophys. Res. Commun. 399(3):434-439(2010) Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009) Benoit, Y.D., et al. Biol. Cell 101(12):695-708(2009) Sato, Y., et al. J. Biol. Chem. 284(21):14524-14536(2009) Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Research Articles on ITGA8
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Products associated with anti-ITGA8 antibody
Pathways associated with anti-ITGA8 antibody
Diseases associated with anti-ITGA8 antibody
Organs/Tissues associated with anti-ITGA8 antibody
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