View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-IkBbeta antibody :: Rabbit IkBbeta Polyclonal Antibody Catalog # MBS440067 Unit / Price 0.2 mg / $300 +1 FREE 8GB USB 5x0.2 mg / $1,170 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name IkBbeta, Polyclonal Antibody Full Product Name IkB-beta (C20) Antibody Product Gene Name anti-IkBbeta antibody[Similar Products] Antibody/Peptide Pairs IkBbeta peptide (MBS443064) is used for blocking the activity of IkBbeta antibody (MBS440067) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Polyclonal Host Rabbit Species Reactivity Mouse, rat, human Specificity Mouse, rat, and human IkBbeta Form/Format 200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. Concentration 0.200 mg/ml (lot specific) Origin IkB-beta (C20) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human IkB-beta. Immunogen Synthetic peptide mapping to the carboxy terminal domain of human IkB-beta Preparation and Storage Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment. Other Notes Small volumes of anti-IkBbeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-IkBbeta antibody The NFkB family of transcription factors is sequestered in the cytoplasm by IkB inhibitory proteins (1&2).IkB-alpha and IkB-beta are the two members of this family most often cited for their regulatory function of NFkB directed gene expression. The interaction of NFkB dimers with IkB proteins keeps the complex in the cytoplasm, but upon cellular stimulation the IkB proteins are phosphorylated and subsequently degraded (1&3). The free NFkB can now enter the nucleus and induce gene expression of proteins critical for cellular proliferation, differentation, or apoptosis (1-4). Applications Tested/Suitable for anti-IkBbeta antibody Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Application Notes for anti-IkBbeta antibody Recommended western blotting starting dilution 1:200. TOP Product References and Citations for anti-IkBbeta antibody 1. Schmitz ML, Baeuerle PA. 1995. Multi-step activation of NF-kappa B/Rel transcription factors. Immunobiology 193(2-4):116-127.2. Tran K, Merika M, Thanos D. 1997. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 17(9):5386-5399.3. Tanaka K, Kawakami T, Tateishi K, Yashiroda H, Chiba T. 2001. Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 83(3-4):351-356.4. Chen CG, Malliaros J, Katerelos M, d?Apice AJ, Pearse MJ. Inhibition of NF-kappaB activation by a dominant-negative mutant of IkappaBalpha. Mol. Immunology 33(1):57-61. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP