NP_001166935.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
kinesin-like protein KIF21A isoform 1
NCBI Official Synonym Full Names
kinesin family member 21A
NCBI Official Synonym Symbols
FEOM1; CFEOM1; FEOM3A; FLJ20052; KIAA1708; DKFZp779C159 [Similar Products]
NCBI Protein Information
kinesin-like protein KIF21A; renal carcinoma antigen NY-REN-62
UniProt Protein Name
Kinesin-like protein KIF21A
UniProt Synonym Protein Names
Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62
UniProt Synonym Gene Names
UniProt Entry Name
KI21A_HUMAN
NCBI Summary for KIF21A
This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.
UniProt Comments for KIF21A
KIF21A: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: microtubule; kinesin complex; cytoplasm
Molecular Function: protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding
Biological Process: metabolic process; microtubule-based movement
Disease: Fibrosis Of Extraocular Muscles, Congenital, 1
Research Articles on KIF21A
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Diseases associated with anti-KIF21A antibody
Organs/Tissues associated with anti-KIF21A antibody
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