Q15726.4
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Metastasis-suppressor KiSS-1
NCBI Official Synonym Full Names
KiSS-1 metastasis-suppressor
NCBI Official Synonym Symbols
NCBI Protein Information
metastasis-suppressor KiSS-1; metastin; kisspeptin-1; prepro-kisspeptin; malignant melanoma metastasis-suppressor
UniProt Protein Name
Metastasis-suppressor KiSS-1
UniProt Synonym Protein Names
Kisspeptin-1Cleaved into the following 4 chains:MetastinAlternative name(s):Kisspeptin-54
UniProt Entry Name
KISS1_HUMAN
NCBI Summary for KISS1
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
UniProt Comments for KISS1
KiSS-1: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Belongs to the KISS1 family.
Protein type: Secreted; Cell adhesion; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular region
Molecular Function: protein binding
Biological Process: cytoskeleton organization and biogenesis
Disease: Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Research Articles on KISS1
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Products associated with anti-KISS1 antibody
Pathways associated with anti-KISS1 antibody
Diseases associated with anti-KISS1 antibody
Disease Name |
Pubmed Publications |
Male Urogenital Diseases Antibodies |
>53 publications with KISS1 and Male Urogenital Diseases |
Genital Diseases, Female Antibodies |
>51 publications with KISS1 and Genital Diseases, Female |
Puberty, Precocious Antibodies |
>47 publications with KISS1 and Puberty, Precocious |
Infertility, Female Antibodies |
>42 publications with KISS1 and Infertility, Female |
Breast Neoplasms Antibodies |
>41 publications with KISS1 and Breast Neoplasms |
Pregnancy Complications Antibodies |
>33 publications with KISS1 and Pregnancy Complications |
Puberty, Delayed Antibodies |
>33 publications with KISS1 and Puberty, Delayed |
Infertility, Male Antibodies |
>30 publications with KISS1 and Infertility, Male |
Adenocarcinoma Antibodies |
>27 publications with KISS1 and Adenocarcinoma |
Ovarian Diseases Antibodies |
>23 publications with KISS1 and Ovarian Diseases |
Organs/Tissues associated with anti-KISS1 antibody
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