NP_002000.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
keratinocyte growth factor
NCBI Official Synonym Full Names
fibroblast growth factor 7
NCBI Official Synonym Symbols
NCBI Protein Information
keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growth factor 7
UniProt Protein Name
Keratinocyte growth factor
UniProt Synonym Protein Names
Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7
UniProt Synonym Gene Names
UniProt Entry Name
FGF7_HUMAN
NCBI Summary for FGF7
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]
UniProt Comments for FGF7
FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: Golgi apparatus; extracellular region
Molecular Function: heparin binding; protein binding; growth factor activity; fibroblast growth factor receptor binding; chemoattractant activity
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; epidermis development; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mesenchymal cell proliferation; signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; response to wounding; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation
Research Articles on FGF7
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Products associated with anti-FGF7 antibody
Pathways associated with anti-FGF7 antibody
Diseases associated with anti-FGF7 antibody
Organs/Tissues associated with anti-FGF7 antibody
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