NP_006139.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,181 Da
NCBI Official Full Name
LIM and SH3 domain protein 1 isoform a
NCBI Official Synonym Full Names
LIM and SH3 protein 1
NCBI Protein Information
LIM and SH3 domain protein 1
UniProt Protein Name
LIM and SH3 domain protein 1
UniProt Synonym Protein Names
Metastatic lymph node gene 50 protein; MLN 50
UniProt Synonym Gene Names
UniProt Entry Name
LASP1_HUMAN
NCBI Summary for LASP1
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
UniProt Comments for LASP1
Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 17q11-q21.3
Cellular Component: cortical actin cytoskeleton; focal adhesion
Molecular Function: actin filament binding; ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity; zinc ion binding
Biological Process: ion transport; positive regulation of signal transduction
Research Articles on LASP1
Precautions
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Products associated with anti-LASP1 antibody
Diseases associated with anti-LASP1 antibody
Disease Name |
Pubmed Publications |
Neoplasm Metastasis Antibodies |
>18 publications with LASP1 and Neoplasm Metastasis |
Liver Neoplasms Antibodies |
>7 publications with LASP1 and Liver Neoplasms |
Carcinoma, Hepatocellular Antibodies |
>5 publications with LASP1 and Carcinoma, Hepatocellular |
Cell Transformation, Neoplastic Antibodies |
>5 publications with LASP1 and Cell Transformation, Neoplastic |
Liver Diseases Antibodies |
>5 publications with LASP1 and Liver Diseases |
Neoplasms, Experimental Antibodies |
>5 publications with LASP1 and Neoplasms, Experimental |
Disease Models, Animal Antibodies |
>2 publications with LASP1 and Disease Models, Animal |
Hyperplasia Antibodies |
>2 publications with LASP1 and Hyperplasia |
Abnormalities, Drug-Induced Antibodies |
>1 publications with LASP1 and Abnormalities, Drug-Induced |
Prenatal Injuries Antibodies |
>1 publications with LASP1 and Prenatal Injuries |
Organs/Tissues associated with anti-LASP1 antibody
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