Q8IWU2
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LMTK2 protein
NCBI Official Synonym Full Names
lemur tyrosine kinase 2
NCBI Official Synonym Symbols
BREK; KPI2; LMR2; cprk; KPI-2; AATYK2; FLJ46659; KIAA1079 [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase LMTK2; hBREK; OTTHUMP00000205379; brain-enriched kinase; CDK5/p35-regulated kinase; kinase phosphatase inhibitor 2; kinase/phosphatase/inhibitor 2; serine/threonine-protein kinase KPI-2; apoptosis-associated tyrosine kinase 2; cyclin-dependent kinase 5/p35-regulated kinase
UniProt Protein Name
Serine/threonine-protein kinase LMTK2
UniProt Synonym Protein Names
Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2; Serine/threonine-protein kinase KPI-2
UniProt Synonym Gene Names
UniProt Entry Name
LMTK2_HUMAN
NCBI Summary for LMTK2
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq]
UniProt Comments for LMTK2
Lmr2: a tyrosine kinase of the Lmr family that apparently phosphorylates Serine and Threonine residues. Associates with PP1C and Inh2 to form a regulatory complex that localizes to membranes. Enriched in brain and muscle. Inhibited in living cells by addition of nerve growth factor or serum. Appears to be inhibited by Cdk5/p35.
Protein type: EC 2.7.11.1; Protein kinase, TK; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, tyrosine (receptor); TK group; Lmr family
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: Golgi apparatus; recycling endosome; perinuclear region of cytoplasm; early endosome; integral to membrane
Molecular Function: protein serine/threonine kinase activity; protein binding; protein phosphatase inhibitor activity; ATP binding
Biological Process: receptor recycling; peptidyl-serine phosphorylation; early endosome to late endosome transport; protein amino acid autophosphorylation; negative regulation of catalytic activity; peptidyl-threonine phosphorylation; transferrin transport; endocytic recycling; protein amino acid phosphorylation
Research Articles on LMTK2
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Diseases associated with anti-LMTK2 antibody
Organs/Tissues associated with anti-LMTK2 antibody
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