AAH01767.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NCBI Official Synonym Full Names
LSM1, U6 small nuclear RNA associated
NCBI Protein Information
U6 snRNA-associated Sm-like protein LSm1; small nuclear ribonuclear CaSm; cancer-associated Sm-like protein; LSM1 homolog, U6 small nuclear RNA associated
UniProt Protein Name
U6 snRNA-associated Sm-like protein LSm1
UniProt Synonym Protein Names
Cancer-associated Sm-like; Small nuclear ribonuclear CaSm
UniProt Synonym Gene Names
UniProt Entry Name
LSM1_HUMAN
NCBI Summary for LSM1
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
UniProt Comments for LSM1
LSM1: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; RNA cap binding
Biological Process: deadenylation-dependent decapping; RNA splicing, via transesterification reactions; RNA splicing; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on LSM1
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Products associated with anti-LSM1 antibody
Pathways associated with anti-LSM1 antibody
Diseases associated with anti-LSM1 antibody
Organs/Tissues associated with anti-LSM1 antibody
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