NP_002361.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,844 Da
NCBI Official Full Name
protein mago nashi homolog
NCBI Official Synonym Full Names
mago homolog, exon junction complex core component
NCBI Protein Information
protein mago nashi homolog
UniProt Protein Name
Protein mago nashi homolog
UniProt Synonym Gene Names
UniProt Entry Name
MGN_HUMAN
NCBI Summary for MAGOH
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
UniProt Comments for MAGOH
MAGOH: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Belongs to the mago nashi family.
Protein type: RNA splicing; Spliceosome
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: mRNA 3'-end processing; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of translation; RNA export from nucleus; termination of RNA polymerase II transcription
Research Articles on MAGOH
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Products associated with anti-MAGOH antibody
Pathways associated with anti-MAGOH antibody
Diseases associated with anti-MAGOH antibody
Organs/Tissues associated with anti-MAGOH antibody
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