NP_001229488.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4 isoform 4
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 4
NCBI Official Synonym Symbols
HGK; NIK; MEKKK4; FLH21957; FLJ10410; FLJ20373; FLJ90111; KIAA0687 [Similar Products]
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 4; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00000207973; OTTHUMP00000207974; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; Ste20 group protein kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 4
UniProt Synonym Protein Names
HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
UniProt Synonym Gene Names
UniProt Entry Name
M4K4_HUMAN
NCBI Summary for MAP4K4
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
UniProt Comments for MAP4K4
HGK: a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; STE group; STE20 family; MSN subfamily
Chromosomal Location of Human Ortholog: 2q11.2-q12
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: microvillus biogenesis; regulation of catalytic activity; regulation of JNK cascade; protein amino acid phosphorylation
Research Articles on MAP4K4
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Products associated with anti-MAP4K4 antibody
Pathways associated with anti-MAP4K4 antibody
Diseases associated with anti-MAP4K4 antibody
Organs/Tissues associated with anti-MAP4K4 antibody
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