View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-MCL-1 antibody :: Rabbit MCL-1 Polyclonal Antibody Catalog # MBS300451 Unit / Price DISCONTINUEDYou will be redirected to our replacement product Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name MCL-1, Polyclonal Antibody Full Product Name Rabbit Anti-Human MCL-1 Polyclonal Antibody Product Gene Name anti-MCL-1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 159552 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity HumanPredicted Reactivity: Bovine, Dog, Mouse, Rabbit, Rat Form/Format 7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. Immunogen Synthetic peptide derived from internal region of human MCL-1. Control Tissue Tonsil Cellular Localization Cytoplasm, Nucleus Entrez Gene Code 4170 Pathway Apoptosis Preparation and Storage Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support. Other Notes Small volumes of anti-MCL-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-MCL-1 antibody MCL-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression of MCL-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. Applications Tested/Suitable for anti-MCL-1 antibody Immunohistochemistry (IHC) Paraffin Application Notes for anti-MCL-1 antibody Immunohistochemistry ProcedureSpecimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.Immunohistochemistry Dilution: Ready To UseIHC Positive Control: Tonsil, Small Intestine Immunohistochemistry (IHC) of anti-MCL-1 antibody Human tonsil stained with anti-MCL-1 antibody TOP NCBI/Uniprot data below describe general gene information for MCL-1. It may not necessarily be applicable to this product. NCBI GI # 309747067 NCBI GeneID 4170 NCBI Accession # NP_001184249.1 [Other Products] NCBI GenBank Nucleotide # NM_001197320.1 [Other Products] UniProt Secondary Accession # Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04[Other Products] UniProt Related Accession # Q07820[Other Products] Molecular Weight 42 kDa TOP NCBI Official Full Name induced myeloid leukemia cell differentiation protein Mcl-1 isoform 3 NCBI Official Synonym Full Names myeloid cell leukemia 1 NCBI Official Symbol MCL1 [Similar Products] NCBI Official Synonym Symbols TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT [Similar Products] NCBI Protein Information induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related) UniProt Protein Name Induced myeloid leukemia cell differentiation protein Mcl-1 UniProt Synonym Protein Names Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT UniProt Gene Name MCL1 [Similar Products] UniProt Synonym Gene Names BCL2L3; Bcl2-L-3 [Similar Products] UniProt Entry Name MCL1_HUMAN TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-MCL-1 antibody Products by Pathway Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Modulation And Signaling Pathway antibodies Apoptosis Modulation And Signaling Pathway Diagram Direct P53 Effectors Pathway antibodies Direct P53 Effectors Pathway Diagram E2F Transcription Factor Network Pathway antibodies E2F Transcription Factor Network Pathway Diagram HIF-1-alpha Transcription Factor Network Pathway antibodies HIF-1-alpha Transcription Factor Network Pathway Diagram IL-7 Signaling Pathway antibodies IL-7 Signaling Pathway Diagram IL6-mediated Signaling Events Pathway antibodies IL6-mediated Signaling Events Pathway Diagram MicroRNAs In Cancer Pathway antibodies MicroRNAs In Cancer Pathway Diagram MicroRNAs In Cancer Pathway antibodies MicroRNAs In Cancer Pathway Diagram PI3K-Akt Signaling Pathway antibodies PI3K-Akt Signaling Pathway Diagram Diseases associated with anti-MCL-1 antibody Disease Name Pubmed Publications Adenocarcinoma Antibodies >60 publications with MCL-1 and Adenocarcinoma Lung Neoplasms Antibodies >56 publications with MCL-1 and Lung Neoplasms Necrosis Antibodies >49 publications with MCL-1 and Necrosis Breast Neoplasms Antibodies >42 publications with MCL-1 and Breast Neoplasms Liver Diseases Antibodies >38 publications with MCL-1 and Liver Diseases Liver Neoplasms Antibodies >32 publications with MCL-1 and Liver Neoplasms Neoplasms, Experimental Antibodies >32 publications with MCL-1 and Neoplasms, Experimental Carcinoma, Hepatocellular Antibodies >30 publications with MCL-1 and Carcinoma, Hepatocellular Inflammation Antibodies >28 publications with MCL-1 and Inflammation Multiple Myeloma Antibodies >28 publications with MCL-1 and Multiple Myeloma Organs/Tissues associated with anti-MCL-1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >150 publications with MCL-1 and Blood Lung Antibodies >79 publications with MCL-1 and Lung Liver Antibodies >70 publications with MCL-1 and Liver Bone Antibodies >60 publications with MCL-1 and Bone Bone Marrow Antibodies >44 publications with MCL-1 and Bone Marrow Brain Antibodies >39 publications with MCL-1 and Brain Prostate Antibodies >30 publications with MCL-1 and Prostate Vascular Antibodies >22 publications with MCL-1 and Vascular Skin Antibodies >19 publications with MCL-1 and Skin Lymph Node Antibodies >15 publications with MCL-1 and Lymph Node TOP © 2006-24 MyBioSource.com. 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