NP_001029159.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
dual specificity mitogen-activated protein kinase kinase 5 isoform a
NCBI Official Synonym Full Names
mitogen activated protein kinase kinase 5
NCBI Official Synonym Symbols
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 5
UniProt Synonym Protein Names
MAPK/ERK kinase 5
UniProt Synonym Gene Names
UniProt Entry Name
MP2K5_RAT
NCBI Summary for MAP2K5
kinase involved in signal transduction in the cell [RGD, Feb 2006]
UniProt Comments for MAP2K5
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis
By similarity. Ref.1
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Subunit structure: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI
By similarity.
Subcellular location: Isoform Beta: Cytoplasm › cytosol. Isoform Alpha-1: Membrane. Note: The alternatively spliced exon in alpha isoform resembleconserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.Isoform Alpha-2: Membrane. Note: The alternatively spliced exon in alpha isoform resembleconserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.
Tissue specificity: MEK5 beta is ubiquitously distributed with highest levels in the liver, whereas MEK5 alpha is expressed only in liver and brain.
Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A
By similarity.
Post-translational modification: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases
By similarity.
Sequence similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.
Product References and Citations for anti-MAP2K5 antibody
• Zhou G, Bao ZQ, Dixon JE, (1995) Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270(21):12665-9. • Chao TH, Hayashi M, Tapping RI, Kato Y, Lee JD (1999) MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J. Biol. Chem. 274(51):36035-8. • Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE, Leung HY (2003) MEK5 overexpression is associated with metastatic prostrate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 22(9):1381-9. • Cameron SJ, Abe J, Malik S, Che W, Yang J (2004) Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. J. Biol. Chem. 279(2):1506-12.
Research Articles on MAP2K5
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Pathways associated with anti-MAP2K5 antibody
Diseases associated with anti-MAP2K5 antibody
Organs/Tissues associated with anti-MAP2K5 antibody
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