NP_001040625.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,885 Da
NCBI Official Full Name
neuroepithelial cell-transforming gene 1 protein isoform 1
NCBI Official Synonym Full Names
neuroepithelial cell transforming 1
NCBI Protein Information
neuroepithelial cell-transforming gene 1 protein
UniProt Protein Name
Neuroepithelial cell-transforming gene 1 protein
UniProt Synonym Protein Names
Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8
UniProt Synonym Gene Names
UniProt Entry Name
ARHG8_HUMAN
NCBI Summary for NET1
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for NET1
NET1: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: cytosol; nucleus; plasma membrane
Molecular Function: GTP-Rho binding; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: myoblast migration; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of cell growth; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on NET1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-NET1 antibody
Pathways associated with anti-NET1 antibody
Diseases associated with anti-NET1 antibody
Organs/Tissues associated with anti-NET1 antibody
|