NP_068535.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
NCBI Official Full Name
neurexin 1
NCBI Official Synonym Full Names
neurexin 1
NCBI Official Synonym Symbols
NCBI Protein Information
neurexin 1; neurexin I-beta; neurexin-1-beta; neurexin I-alpha; neurexin-1-alpha; non-processed neurexin I-alpha
UniProt Protein Name
Neurexin-1-alpha
UniProt Synonym Protein Names
Neurexin I-alpha
UniProt Entry Name
NRX1A_RAT
NCBI Summary for Nrxn1
neuronal cell recognition molecule; may have a role in synaptogenesis [RGD]
UniProt Comments for Nrxn1
NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.
Protein type: Receptor, misc.; Membrane protein, integral
Cellular Component: presynaptic membrane; cell surface; endocytic vesicle; cell; integral to membrane; plasma membrane; cell junction
Molecular Function: protein binding; calcium channel regulator activity; acetylcholine receptor binding; calcium ion binding; cell adhesion molecule binding; calcium-dependent protein binding; receptor binding
Biological Process: prepulse inhibition; neurotransmitter secretion; vocal learning; social behavior; learning; positive regulation of synaptic transmission, glutamatergic; cerebellar granule cell differentiation; negative regulation of filopodium formation; heterophilic cell adhesion; positive regulation of synaptogenesis; synaptic transmission; establishment of protein localization; synaptogenesis; adult behavior; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; angiogenesis; cell adhesion; neuromuscular process controlling balance; vesicle docking during exocytosis
Research Articles on Nrxn1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-Nrxn1 antibody
Pathways associated with anti-Nrxn1 antibody
Diseases associated with anti-Nrxn1 antibody
Organs/Tissues associated with anti-Nrxn1 antibody
|