NP_006165.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,727 Da
NCBI Official Full Name
neuropeptide Y receptor type 5
NCBI Official Synonym Full Names
neuropeptide Y receptor Y5
NCBI Protein Information
neuropeptide Y receptor type 5
UniProt Protein Name
Neuropeptide Y receptor type 5
UniProt Synonym Protein Names
NPY-Y5 receptor; NPYY5-R; Y5 receptor
UniProt Synonym Gene Names
UniProt Entry Name
NPY5R_HUMAN
NCBI Summary for NPY5R
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Comments for NPY5R
NPY5R: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q31-q32
Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity
Biological Process: cell surface receptor linked signal transduction; eating behavior; feeding behavior; G-protein coupled receptor protein signaling pathway; generation of ovulation cycle rhythm; negative regulation of apoptosis; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; neuropeptide signaling pathway; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation; synaptic transmission
Research Articles on NPY5R
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Pathways associated with anti-NPY5R antibody
Diseases associated with anti-NPY5R antibody
Organs/Tissues associated with anti-NPY5R antibody
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