AAI07724.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,677 Da
NCBI Official Full Name
OBFC2A protein
NCBI Official Synonym Full Names
nucleic acid binding protein 1
NCBI Protein Information
SOSS complex subunit B2
UniProt Protein Name
SOSS complex subunit B2
UniProt Synonym Protein Names
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
UniProt Synonym Gene Names
NCBI Summary for OBFC2A
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
UniProt Comments for OBFC2A
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Product References and Citations for anti-OBFC2A antibody
(1) Li, Y., Bolderson, E., Kumar, R., et al. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J. Biol. Chem. 284 (35), 23525-23531 (2009).
Research Articles on OBFC2A
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Organs/Tissues associated with anti-OBFC2A antibody
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