P22777.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
Plasminogen activator inhibitor 1
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade E, member 1
NCBI Protein Information
plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activator inhibitor, type I; endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
UniProt Protein Name
Plasminogen activator inhibitor 1
UniProt Synonym Protein Names
Endothelial plasminogen activator inhibitor; Serpin E1
UniProt Synonym Gene Names
UniProt Entry Name
PAI1_MOUSE
UniProt Comments for SERPINE1
SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; extracellular space; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; protease inhibitor activity; receptor binding
Biological Process: positive regulation of keratinocyte migration; positive regulation of blood coagulation; wound healing; negative regulation of peptidase activity; positive regulation of coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; regulation of angiogenesis; positive regulation of receptor-mediated endocytosis; regulation of cell proliferation; positive regulation of interleukin-8 production; positive regulation of fibroblast proliferation; positive regulation of angiogenesis; negative regulation of fibrinolysis; regulation of receptor activity; negative regulation of cell migration; negative regulation of cell adhesion mediated by integrin; female gonad development; positive regulation of inflammatory response
Research Articles on SERPINE1
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Pathways associated with anti-SERPINE1 antibody
Organs/Tissues associated with anti-SERPINE1 antibody
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