NP_055271.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,576 Da
NCBI Official Full Name
programmed cell death protein 4 isoform 1
NCBI Official Synonym Full Names
programmed cell death 4
NCBI Official Synonym Symbols
NCBI Protein Information
programmed cell death protein 4
UniProt Protein Name
Programmed cell death protein 4
UniProt Synonym Protein Names
Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a
UniProt Synonym Gene Names
NCBI Summary for PDCD4
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
UniProt Comments for PDCD4
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA ().
Product References and Citations for anti-PDCD4 antibody
(1)Bitomsky, N., Wethkamp, N., Marikkannu, R. et al. siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression. Oncogene 27 (35), 4820-4829 (2008).
Research Articles on PDCD4
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Products associated with anti-PDCD4 antibody
Pathways associated with anti-PDCD4 antibody
Diseases associated with anti-PDCD4 antibody
Organs/Tissues associated with anti-PDCD4 antibody
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