NP_001165290.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
peroxisome proliferator-activated receptor delta isoform 3
NCBI Official Synonym Full Names
peroxisome proliferator-activated receptor delta
NCBI Official Synonym Symbols
FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; MGC3931 [Similar Products]
NCBI Protein Information
peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; OTTHUMP00000016256; OTTHUMP00000016257; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2
UniProt Protein Name
Peroxisome proliferator-activated receptor delta
UniProt Synonym Protein Names
NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta
UniProt Synonym Gene Names
UniProt Entry Name
PPARD_HUMAN
NCBI Summary for PPARD
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq]
UniProt Comments for PPARD
PPAR-delta: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Belongs to the nuclear hormone receptor family. NR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: NF-kappaB binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; drug binding; lipid binding; transcription factor activity
Biological Process: proteoglycan metabolic process; wound healing; negative regulation of smooth muscle cell proliferation; heart development; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; positive regulation of epidermis development; glucose transport; decidualization; negative regulation of smooth muscle cell migration; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; vitamin A metabolic process; response to vitamin A; positive regulation of cell proliferation; response to glucose stimulus; axon ensheathment; cell differentiation; negative regulation of epithelial cell proliferation; cholesterol metabolic process; transcription initiation from RNA polymerase II promoter; generation of precursor metabolites and energy; intracellular receptor-mediated signaling pathway; glucose metabolic process; positive regulation of insulin secretion; fatty acid catabolic process; keratinocyte proliferation; cell-substrate adhesion; keratinocyte migration; phospholipid biosynthetic process; regulation of transcription from RNA polymerase II promoter; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; fatty acid beta-oxidation; negative regulation of inflammatory response; mRNA transcription; positive regulation of fat cell differentiation; gene expression; steroid hormone mediated signaling; response to activity; negative regulation of cell growth; lipid metabolic process; negative regulation of transcription, DNA-dependent; fatty acid transport; embryo implantation; negative regulation of apoptosis
Research Articles on PPARD
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Products associated with anti-PPARD antibody
Pathways associated with anti-PPARD antibody
Diseases associated with anti-PPARD antibody
Organs/Tissues associated with anti-PPARD antibody
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