P35236.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 7
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 7
NCBI Official Synonym Symbols
LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP [Similar Products]
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 7; dual specificity phosphatase 1; protein-tyrosine phosphatase LC-PTP; hematopoietic protein-tyrosine phosphatase; protein-tyrosine phosphatase, nonreceptor-type, stress induced
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 7
UniProt Synonym Protein Names
Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP
UniProt Synonym Gene Names
UniProt Entry Name
PTN7_HUMAN
NCBI Summary for PTPN7
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for PTPN7
HePTP: a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm; cytosol
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Research Articles on PTPN7
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Products associated with anti-PTPN7 antibody
Pathways associated with anti-PTPN7 antibody
Diseases associated with anti-PTPN7 antibody
Organs/Tissues associated with anti-PTPN7 antibody
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