NP_001189360.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
peroxiredoxin-1
NCBI Official Synonym Full Names
peroxiredoxin 1
NCBI Official Synonym Symbols
PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A [Similar Products]
NCBI Protein Information
peroxiredoxin-1
UniProt Protein Name
Peroxiredoxin-1
UniProt Synonym Protein Names
Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
UniProt Synonym Gene Names
UniProt Entry Name
PRDX1_HUMAN
NCBI Summary for PRDX1
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for PRDX1
PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression.
Protein type: Oxidoreductase; Nuclear receptor co-regulator; EC 1.11.1.15
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: cytoplasm; cytosol; extracellular space; melanosome; mitochondrion; myelin sheath; nucleus
Molecular Function: identical protein binding; peroxidase activity; protein binding; thioredoxin peroxidase activity
Biological Process: cell proliferation; erythrocyte homeostasis; gene expression; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; regulation of NF-kappaB import into nucleus; regulation of stress-activated MAPK cascade; removal of superoxide radicals; response to reactive oxygen species; retinal homeostasis; skeletal development; transcription initiation from RNA polymerase II promoter
Research Articles on PRDX1
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Products associated with anti-PRDX1 antibody
Pathways associated with anti-PRDX1 antibody
Diseases associated with anti-PRDX1 antibody
Organs/Tissues associated with anti-PRDX1 antibody
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