NP_038681.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
C-C motif chemokine 5
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 5
NCBI Official Synonym Symbols
SISd; Scya5; RANTES; TCP228; MuRantes [Similar Products]
NCBI Protein Information
C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; small inducible cytokine A5; small-inducible cytokine A5
UniProt Protein Name
C-C motif chemokine 5
UniProt Synonym Protein Names
MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES
UniProt Synonym Gene Names
UniProt Entry Name
CCL5_MOUSE
UniProt Comments for Ccl5
CCL5: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. By mitogens. T-cell and macrophage specific. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Cell adhesion; Chemokine; Motility/polarity/chemotaxis; Secreted
Cellular Component: extracellular space; cell; cytoplasm; extracellular region; intracellular
Molecular Function: heparin binding; protein homodimerization activity; protein self-association; cytokine activity; receptor signaling protein tyrosine kinase activator activity; phosphoinositide phospholipase C activity; protein kinase activity; CCR1 chemokine receptor binding; chemokine receptor binding; chemokine activity; chemokine receptor antagonist activity; chemoattractant activity; phospholipase activator activity; CCR5 chemokine receptor binding
Biological Process: positive regulation of cell adhesion; exocytosis; positive regulation of osteoclast differentiation; response to toxin; positive regulation of smooth muscle cell proliferation; chemotaxis; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of homotypic cell-cell adhesion; pseudopodium formation; leukocyte adhesion; cell-cell signaling; positive chemotaxis; calcium ion transport; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; inflammatory response; lymphocyte chemotaxis; protein tetramerization; phospholipase D activation; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; MAPKKK cascade; positive regulation of cellular biosynthetic process; cellular calcium ion homeostasis; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cellular protein complex assembly; negative regulation of viral genome replication; positive regulation of tyrosine phosphorylation of STAT protein; response to cytokine stimulus; eosinophil chemotaxis; positive regulation of fever; immune response; positive regulation of neuron differentiation; positive regulation of calcium ion transport; positive regulation of defense response to virus by host; regulation of insulin secretion; positive regulation of epithelial cell proliferation; positive regulation of phosphorylation; regulation of T cell activation; positive regulation of cell migration
Research Articles on Ccl5
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Products associated with anti-Ccl5 antibody
Pathways associated with anti-Ccl5 antibody
Diseases associated with anti-Ccl5 antibody
Organs/Tissues associated with anti-Ccl5 antibody
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