NP_079215
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,364 Da
NCBI Official Full Name
epithelial splicing regulatory protein 2
NCBI Official Synonym Full Names
epithelial splicing regulatory protein 2
NCBI Official Synonym Symbols
NCBI Protein Information
epithelial splicing regulatory protein 2; RNA-binding protein 35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA-binding motif protein 35B
UniProt Protein Name
Epithelial splicing regulatory protein 2
UniProt Synonym Protein Names
RNA-binding motif protein 35B; RNA-binding protein 35B
UniProt Synonym Gene Names
UniProt Entry Name
ESRP2_HUMAN
NCBI Summary for ESRP2
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
UniProt Comments for ESRP2
RBM35B: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: mRNA binding; nucleotide binding
Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing
Research Articles on ESRP2
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Products associated with anti-ESRP2 antibody
Diseases associated with anti-ESRP2 antibody
Organs/Tissues associated with anti-ESRP2 antibody
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