NP_065690.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
receptor-interacting serine/threonine-protein kinase 4
NCBI Official Synonym Full Names
receptor-interacting serine-threonine kinase 4
NCBI Official Synonym Symbols
DIK; PKK; RIP4; ANKK2; ANKRD3; MGC129992; MGC129993 [Similar Products]
NCBI Protein Information
receptor-interacting serine/threonine-protein kinase 4; OTTHUMP00000109266; ankyrin repeat domain 3; PKC-delta-interacting protein kinase; serine/threonine-protein kinase ANKRD3; ankyrin repeat domain-containing protein 3
UniProt Protein Name
Receptor-interacting serine-threonine kinase 4
UniProt Entry Name
Q2TB16_HUMAN
NCBI Summary for RIPK4
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq]
UniProt Comments for RIPK4
ANKRD3: a TKL protein kinase of the RIPK family. Activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. Appears to activate NFkappaB in both a kinase-dependent as well as a kinase-independent manner. Contains 10 ANK repeats. Two alternatively spliced isoforms have been described.
Protein type: Protein kinase, TKL; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RIPK family
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: membrane; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: morphogenesis of an epithelium; protein amino acid phosphorylation; activation of NF-kappaB transcription factor
Disease: Popliteal Pterygium Syndrome, Lethal Type
Research Articles on RIPK4
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Organs/Tissues associated with anti-RIPK4 antibody
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