NP_001028675.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,410 Da
NCBI Official Full Name
GTP-binding protein SAR1b
NCBI Official Synonym Full Names
secretion associated Ras related GTPase 1B
NCBI Protein Information
GTP-binding protein SAR1b
UniProt Protein Name
GTP-binding protein SAR1b
UniProt Synonym Protein Names
GTP-binding protein B; GTBPB
UniProt Synonym Gene Names
UniProt Entry Name
SAR1B_HUMAN
NCBI Summary for SAR1B
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for SAR1B
SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, SAR1; G protein
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cytosol; endoplasmic reticulum membrane
Molecular Function: GTP binding; GTPase activity; metal ion binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; small GTPase mediated signal transduction
Disease: Chylomicron Retention Disease
Research Articles on SAR1B
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Pathways associated with anti-SAR1B antibody
Diseases associated with anti-SAR1B antibody
Organs/Tissues associated with anti-SAR1B antibody
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