NP_065105.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,712 Da
NCBI Official Full Name
solute carrier family 22 member 17 isoform a
NCBI Official Synonym Full Names
solute carrier family 22, member 17
NCBI Official Synonym Symbols
BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3 [Similar Products]
NCBI Protein Information
solute carrier family 22 member 17; 24p3 receptor; NGAL receptor; lipocalin-2 receptor; brain-type organic cation transporter; potent brain type organic ion transporter; neutrophil gelatinase-associated lipocalin receptor; solute carrier family 22 (organic cation transporter), member 17
UniProt Protein Name
Solute carrier family 22 member 17
UniProt Synonym Protein Names
24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR
UniProt Synonym Gene Names
UniProt Entry Name
S22AH_HUMAN
UniProt Comments for SLC22A17
SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: integral to plasma membrane; vacuolar membrane
Molecular Function: transmembrane receptor activity; transmembrane transporter activity
Biological Process: cellular iron ion homeostasis; siderophore transport; ion transport; signal transduction; transmembrane transport
Research Articles on SLC22A17
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Products associated with anti-SLC22A17 antibody
Pathways associated with anti-SLC22A17 antibody
Diseases associated with anti-SLC22A17 antibody
Organs/Tissues associated with anti-SLC22A17 antibody
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