NP_008932
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,702 Da
NCBI Official Full Name
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a
NCBI Official Synonym Full Names
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
NCBI Protein Information
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8
UniProt Protein Name
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
UniProt Synonym Protein Names
Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8
UniProt Synonym Gene Names
UniProt Entry Name
S35D2_HUMAN
NCBI Summary for SLC35D2
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
UniProt Comments for SLC35D2
SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q22.32
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: nucleotide-sugar transmembrane transporter activity
Biological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate transport; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; transmembrane transport
Research Articles on SLC35D2
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Products associated with anti-SLC35D2 antibody
Pathways associated with anti-SLC35D2 antibody
Diseases associated with anti-SLC35D2 antibody
Organs/Tissues associated with anti-SLC35D2 antibody
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