NP_071899.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
44,117 Da
NCBI Official Full Name
transcription factor SOX-17
NCBI Official Synonym Full Names
SRY-box 17
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor SOX-17
UniProt Protein Name
Transcription factor SOX-17
UniProt Entry Name
SOX17_HUMAN
NCBI Summary for SOX17
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for SOX17
SOX17: Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3). VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
Protein type: DNA-binding; Transcription regulation
Chromosomal Location of Human Ortholog: 8q11.23
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: beta-catenin binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding
Biological Process: angiogenesis; cell migration involved in gastrulation; embryonic foregut morphogenesis; embryonic heart tube development; endoderm formation; endodermal cell fate determination; heart looping; inner cell mass cellular morphogenesis; mRNA transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of mesodermal cell fate specification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of protein catabolic process; positive regulation of skeletal muscle development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein destabilization; protein stabilization; regulation of embryonic development; regulation of transcription, DNA-dependent; rostrocaudal neural tube patterning; spermatogenesis; stem cell fate specification; vasculogenesis; Wnt receptor signaling pathway through beta-catenin
Disease: Vesicoureteral Reflux 3
Research Articles on SOX17
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Products associated with anti-SOX17 antibody
Pathways associated with anti-SOX17 antibody
Diseases associated with anti-SOX17 antibody
Organs/Tissues associated with anti-SOX17 antibody
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