NP_689807.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sprouty-related, EVH1 domain-containing protein 1
NCBI Official Synonym Full Names
sprouty-related, EVH1 domain containing 1
NCBI Protein Information
sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
UniProt Protein Name
Sprouty-related, EVH1 domain-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SPRE1_HUMAN
NCBI Summary for SPRED1
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
UniProt Comments for SPRED1
SPRED1: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS). It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: nucleoplasm; cytoplasm; caveola
Molecular Function: protein serine/threonine kinase inhibitor activity; protein binding; stem cell factor receptor binding; protein kinase binding; phosphatase binding
Biological Process: multicellular organismal development; positive regulation of DNA damage response, signal transduction by p53 class mediator; inactivation of MAPK activity
Disease: Legius Syndrome
Research Articles on SPRED1
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Products associated with anti-SPRED1 antibody
Pathways associated with anti-SPRED1 antibody
Diseases associated with anti-SPRED1 antibody
Organs/Tissues associated with anti-SPRED1 antibody
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