NP_009109.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,778 Da
NCBI Official Full Name
serine-threonine kinase receptor-associated protein
NCBI Official Synonym Full Names
serine/threonine kinase receptor associated protein
NCBI Protein Information
serine-threonine kinase receptor-associated protein
UniProt Protein Name
Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names
MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
UniProt Synonym Gene Names
UniProt Comments for STRAP
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Research Articles on STRAP
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Products associated with anti-STRAP antibody
Pathways associated with anti-STRAP antibody
Diseases associated with anti-STRAP antibody
Organs/Tissues associated with anti-STRAP antibody
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