NP_001006618.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,838 Da
NCBI Official Full Name
target of rapamycin complex 2 subunit MAPKAP1 isoform 1
NCBI Official Synonym Full Names
mitogen-activated protein kinase associated protein 1
NCBI Official Synonym Symbols
MIP1; SIN1; JC310; SIN1b; SIN1g [Similar Products]
NCBI Protein Information
target of rapamycin complex 2 subunit MAPKAP1
UniProt Protein Name
Target of rapamycin complex 2 subunit MAPKAP1
UniProt Synonym Protein Names
Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1
UniProt Synonym Gene Names
MIP1; SIN1; TORC2 subunit MAPKAP1; SAPK-interacting protein 1; mSIN1 [Similar Products]
NCBI Summary for Sin1
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for Sin1
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Product References and Citations for anti-Sin1 antibody
(1) Ghosh, D., Srivastava, G.P., Xu, D., et al.A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proc. Natl. Acad. Sci. U.S.A. 105 (33), 11673-11678 (2008).
Research Articles on Sin1
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Pathways associated with anti-Sin1 antibody
Diseases associated with anti-Sin1 antibody
Organs/Tissues associated with anti-Sin1 antibody
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