AF203914
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Mus musculus direct IAP binding protein with low PI mRNA, complete cds
NCBI Official Synonym Full Names
diablo homolog (Drosophila)
NCBI Official Synonym Symbols
Smac; AU040403; 0610041G12Rik; 1700006L01Rik [Similar Products]
NCBI Protein Information
diablo homolog, mitochondrial; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase
UniProt Protein Name
Diablo homolog, mitochondrial
UniProt Synonym Protein Names
Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
UniProt Synonym Gene Names
UniProt Entry Name
DBLOH_MOUSE
UniProt Comments for Diablo
DIABLO: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. Homodimer. Interacts with NGFRAP1/BEX3. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the monomeric and dimeric form of BIRC5/survivin. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Mitochondrial
Cellular Component: internal side of plasma membrane; mitochondrion; cytoplasm; mitochondrial intermembrane space
Biological Process: caspase activation; neuron apoptosis; apoptosis; positive regulation of apoptosis; caspase activation via cytochrome c; induction of apoptosis by oxidative stress
Research Articles on Diablo
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Pathways associated with anti-Diablo antibody
Diseases associated with anti-Diablo antibody
Organs/Tissues associated with anti-Diablo antibody
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