NP_963925
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,919 Da
NCBI Official Full Name
protein-glutamine gamma-glutamyltransferase 5 isoform 1
NCBI Official Synonym Full Names
transglutaminase 5
NCBI Official Synonym Symbols
TGX; PSS2; TGM6; TGMX; TGASE5; TGASEX [Similar Products]
NCBI Protein Information
protein-glutamine gamma-glutamyltransferase 5; TG(X); TGase X; TGase-5; transglutaminase V; transglutaminase X; transglutaminase-5
UniProt Protein Name
Protein-glutamine gamma-glutamyltransferase 5
UniProt Synonym Protein Names
Transglutaminase X; TG(X); TGX; TGase X; Transglutaminase-5; TGase-5
UniProt Synonym Gene Names
UniProt Entry Name
TGM5_HUMAN
NCBI Summary for TGM5
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
UniProt Comments for TGM5
TGM5: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. Defects in TGM5 are a cause of peeling skin syndrome type A (APSS). A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.3.2.13
Chromosomal Location of Human Ortholog: 15q15.2
Cellular Component: cytoplasm
Molecular Function: protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: epidermis development; protein modification process; peptide cross-linking
Disease: Peeling Skin Syndrome 2
Research Articles on TGM5
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Products associated with anti-TGM5 antibody
Diseases associated with anti-TGM5 antibody
Organs/Tissues associated with anti-TGM5 antibody
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