NP_109607.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,673 Da
NCBI Official Full Name
toll-like receptor 1
NCBI Official Synonym Full Names
toll-like receptor 1
NCBI Protein Information
toll-like receptor 1
UniProt Protein Name
Toll-like receptor 1
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein; TIL; CD_antigen: CD281
UniProt Synonym Gene Names
UniProt Entry Name
TLR1_MOUSE
UniProt Comments for TLR1
TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral
Cellular Component: cytoplasmic vesicle; Golgi apparatus; integral to membrane; integral to plasma membrane; lipid raft; membrane; phagocytic vesicle; plasma membrane
Molecular Function: protein heterodimerization activity; transmembrane receptor activity; triacylated lipoprotein binding
Biological Process: activation of NF-kappaB-inducing kinase; defense response; defense response to bacterium; detection of triacylated bacterial lipoprotein; immune response; immune system process; inflammatory response; innate immune response; macrophage activation; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; response to bacterial lipoprotein; signal transduction; toll-like receptor 1 signaling pathway; toll-like receptor signaling pathway
Research Articles on TLR1
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Products associated with anti-TLR1 antibody
Pathways associated with anti-TLR1 antibody
Diseases associated with anti-TLR1 antibody
Organs/Tissues associated with anti-TLR1 antibody
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