NP_001061.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tubulin gamma-1 chain
NCBI Official Synonym Full Names
tubulin, gamma 1
NCBI Protein Information
tubulin gamma-1 chain; gamma-tubulin complex component 1; tubulin, gamma polypeptide
UniProt Protein Name
Tubulin gamma-1 chain
UniProt Synonym Protein Names
Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1
UniProt Synonym Gene Names
UniProt Entry Name
TBG1_HUMAN
NCBI Summary for TUBG1
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
UniProt Comments for TUBG1
TUBG1: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: centriole; centrosome; pericentriolar material; recycling endosome; condensed nuclear chromosome; cytoplasmic microtubule; apical part of cell; nonmotile primary cilium; leading edge; cytoplasm; polar microtubule; cytosol; gamma-tubulin complex
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: metabolic process; organelle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule nucleation; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 4
Research Articles on TUBG1
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Pathways associated with anti-TUBG1 antibody
Diseases associated with anti-TUBG1 antibody
Organs/Tissues associated with anti-TUBG1 antibody
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