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Add To Compare List anti-TH antibody :: Rabbit anti-Rat Tyrosine Hydroxylase Polyclonal Antibody Catalog # MBS624954 Unit / Price 0.1 mL / $820 +1 FREE 8GB USB 5x0.1 mL / $3,520 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Tyrosine Hydroxylase (TH), Polyclonal Antibody Full Product Name Tyrosine Hydroxylase, phosphorylated (Ser31) (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase) Product Synonym Names Anti -Tyrosine Hydroxylase, phosphorylated (Ser31) (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase) Product Gene Name anti-TH antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 11; NC_000011.9 (2185159..2193035, complement). Location: 11p15.5 3D Structure ModBase 3D Structure for O43816 Clonality Polyclonal Host Rabbit Species Reactivity Rat Specificity Specific for rat TH phosphorylated at Ser31. On Western blots, it identifies a single band at ~60kD. Reactivity has been confirmed with PC-12 cell lysates stimulated by okadaic acid. Purity/Purification PurifiedSupplied as a liquid in sequential chromatography on phospho- and nonphospho- peptide affinity columns Form/Format Supplied as a liquid in 10mM HEPES, pH 7.5, 150 mM NaCl, 0.1mg/ml BSA and 50% glycerol. Immunogen Synthetic phospho peptide derived from a region of the rat tyrosine hydroxylase (TH) protein surrounding the phosphorylated Ser31 residue. Preparation and Storage May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-TH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-TH antibody Tyrosine hydroxylase (TH) plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines dopamine and norepinephrine from tyrosine. TH is therefore a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Phosphorylation of Ser31 can activate TH in vitro, and has been observed at this residue following NGF, phorbol ester, and diacylglycerol treatment of PC12 cells. Ser31 has been identified as a membrane depolarization-dependent and growth factor-sensitive phosphorylation site. Product Categories/Family for anti-TH antibody Antibodies; Abs to Proteins Applications Tested/Suitable for anti-TH antibody Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) Application Notes for anti-TH antibody Suitable for use in Western Blot, Immunofluorescence, and Immunohistochemistry.Dilution: Western Blot: 1:1000Immunofluorescence: 1:1000Immunohistochemistry: 1:1000 TOP NCBI/Uniprot data below describe general gene information for TH. It may not necessarily be applicable to this product. NCBI GI # 986909 NCBI GeneID 7054 UniProt Primary Accession # O43816 [Other Products] UniProt Related Accession # O43816; P07101; P78428; Q0PWM2; Q0PWM3; Q15587; Q16846; Q2M3B4; Q6XS77; Q7KZ36[Other Products] Molecular Weight 14,058 Da[Similar Products] TOP NCBI Official Full Name tyrosine hydroxylase NCBI Official Synonym Full Names tyrosine hydroxylase NCBI Official Symbol TH [Similar Products] NCBI Official Synonym Symbols TYH; DYT14; DYT5b [Similar Products] NCBI Protein Information tyrosine 3-monooxygenase; dystonia 14; OTTHUMP00000011163; OTTHUMP00000011225; OTTHUMP00000011226; tyrosine 3-hydroxylase UniProt Protein Name Tyrosine hydroxylase UniProt Entry Name O43816_HUMAN TOP NCBI Summary for TH The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq] TOP UniProt Comments for TH TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Protein type: Mitochondrial; Oxidoreductase; Vesicle; Endoplasmic reticulum; EC 1.14.16.2; Amino Acid Metabolism - tyrosineChromosomal Location of Human Ortholog: 11p15.5Cellular Component: synaptic vesicle; neuron projection; internal side of plasma membrane; smooth endoplasmic reticulum; mitochondrion; cytoplasm; dendrite; melanosome membrane; terminal button; perikaryon; cytoplasmic vesicle; nucleus; cytosolMolecular Function: amino acid binding; protein domain specific binding; protein binding; enzyme binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activityBiological Process: heart morphogenesis; synaptic transmission, dopaminergic; response to peptide hormone stimulus; heart development; response to lipopolysaccharide; locomotory behavior; dopamine biosynthetic process; fatty acid metabolic process; regulation of heart contraction; phytoalexin metabolic process; response to salt stress; response to estradiol stimulus; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; sensory perception of sound; visual perception; response to electrical stimulus; glycoside metabolic process; epinephrine biosynthetic process; response to pyrethroid; neurotransmitter biosynthetic process; response to corticosterone stimulus; response to nutrient levels; response to light stimulus; anatomical structure morphogenesis; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; phthalate metabolic process; mating behavior; multicellular organismal aging; isoquinoline alkaloid metabolic process; social behavior; response to herbicide; learning; response to ether; synaptic vesicle amine transport; memory; eye photoreceptor cell development; organ morphogenesis; circadian sleep/wake cycle; response to ethanol; pigmentation; response to zinc ion; response to hypoxia; embryonic camera-type eye morphogenesis; response to activity; cerebral cortex development; response to water deprivationDisease: Segawa Syndrome, Autosomal Recessive Research Articles on TH 1. These results suggest that the phosphorylation of the N-terminal portion of TH regulates the degradation of this enzyme by the ubiquitin-proteasome pathway. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. 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TOP Products associated with anti-TH antibody Reference Product PubMed Publications MAPK1 antibody >1028 publications with TH and MAPK1 SNCA antibody >87 publications with TH and SNCA MAPKAPK2 antibody >48 publications with TH and MAPKAPK2 MAPK3 antibody >5 publications with TH and MAPK3 CAMK2G antibody >5 publications with TH and CAMK2G YWHAZ antibody >4 publications with TH and YWHAZ YWHAB antibody >4 publications with TH and YWHAB Pathways associated with anti-TH antibody Products by Pathway Pathway Diagram ATF-2 Transcription Factor Network Pathway antibodies ATF-2 Transcription Factor Network Pathway Diagram Alpha-synuclein Signaling Pathway antibodies Alpha-synuclein Signaling Pathway Diagram Amine-derived Hormones Pathway antibodies Amine-derived Hormones Pathway Diagram Biogenic Amine Synthesis Pathway antibodies Biogenic Amine Synthesis Pathway Diagram Biosynthesis Of Amine And Peptide Hormones Pathway antibodies Biosynthesis Of Amine And Peptide Hormones Pathway Diagram Catecholamine Biosynthesis Pathway antibodies Catecholamine Biosynthesis Pathway Diagram Dopamine Neurotransmitter Release Cycle Pathway antibodies Dopamine Neurotransmitter Release Cycle Pathway Diagram Metabolic Pathways antibodies Metabolic Pathways Diagram Metabolism Of Amino Acids And Derivatives Pathway antibodies Metabolism Of Amino Acids And Derivatives Pathway Diagram Metabolism Of Hormones Pathway antibodies Metabolism Of Hormones Pathway Diagram Diseases associated with anti-TH antibody Disease Name Pubmed Publications Neoplasms Antibodies >1105530 publications with TH and Neoplasms Cardiovascular Diseases Antibodies >883656 publications with TH and Cardiovascular Diseases Nervous System Diseases Antibodies >811276 publications with TH and Nervous System Diseases Heart Diseases Antibodies >447261 publications with TH and Heart Diseases Brain Diseases Antibodies >383626 publications with TH and Brain Diseases Mental Disorders Antibodies >375178 publications with TH and Mental Disorders Gastrointestinal Diseases Antibodies >357618 publications with TH and Gastrointestinal Diseases Pain Antibodies >290199 publications with TH and Pain Kidney Diseases Antibodies >194714 publications with TH and Kidney Diseases Myocardial Ischemia Antibodies >190640 publications with TH and Myocardial Ischemia Organs/Tissues associated with anti-TH antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >237302 publications with TH and Brain Eye Antibodies >127559 publications with TH and Eye Nerve Antibodies >108344 publications with TH and Nerve Mouth Antibodies >92340 publications with TH and Mouth Pancreas Antibodies >36230 publications with TH and Pancreas Adrenal Gland Antibodies >18173 publications with TH and Adrenal Gland Embryonic Tissue Antibodies >14286 publications with TH and Embryonic Tissue Placenta Antibodies >7810 publications with TH and Placenta Uncharacterized Tissue Antibodies >80 publications with TH and Uncharacterized Tissue TOP © 2006-24 MyBioSource.com. 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