NP_116572.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Williams-Beuren syndrome chromosomal region 14 protein isoform delta
NCBI Official Synonym Full Names
MLX interacting protein-like
NCBI Official Synonym Symbols
MIO; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14 [Similar Products]
NCBI Protein Information
Williams-Beuren syndrome chromosomal region 14 protein; Mlx interactor; OTTHUMP00000160457; OTTHUMP00000160458; OTTHUMP00000211546; OTTHUMP00000211547; OTTHUMP00000225492; OTTHUMP00000225493; MLX-interacting protein-like; class D basic helix-loop-helix protein 14; Williams Beuren syndrome chromosome region 14; carbohydrate response element binding protein; carbohydrate-responsive element-binding protein; WS basic-helix-loop-helix leucine zipper protein; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2
UniProt Protein Name
Williams-Beuren syndrome chromosomal region 14 protein
UniProt Synonym Protein Names
Class D basic helix-loop-helix protein 14; bHLHd14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein
UniProt Synonym Gene Names
UniProt Entry Name
WBS14_HUMAN
NCBI Summary for MLXIPL
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq]
UniProt Comments for MLXIPL
ChREBP: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. Binds DNA as a heterodimer with TCFL4/MLX. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus
Molecular Function: protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity
Biological Process: positive regulation of fatty acid biosynthetic process; anatomical structure morphogenesis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of peptidyl-serine phosphorylation; positive regulation of cellular metabolic process; positive regulation of lipid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; glucose mediated signaling; regulation of transcription from RNA polymerase II promoter; regulation of fatty acid biosynthetic process; regulation of transcription, DNA-dependent; fatty acid homeostasis; positive regulation of cell proliferation; positive regulation of glycolysis; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Williams-beuren Syndrome
Research Articles on MLXIPL
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Products associated with anti-MLXIPL antibody
Pathways associated with anti-MLXIPL antibody
Diseases associated with anti-MLXIPL antibody
Organs/Tissues associated with anti-MLXIPL antibody
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