NP_954590.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
XIAP-associated factor 1 isoform 2
NCBI Official Synonym Full Names
XIAP associated factor 1
NCBI Protein Information
XIAP-associated factor 1; BIRC4 binding protein; BIRC4-binding protein
UniProt Protein Name
XIAP-associated factor 1
UniProt Synonym Protein Names
BIRC4-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
XAF1_HUMAN
NCBI Summary for XAF1
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for XAF1
BIRC4BP: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: mitochondrion; nucleus; cytosol
Molecular Function: zinc ion binding
Biological Process: apoptosis; cytokine and chemokine mediated signaling pathway; negative regulation of protein complex assembly
Research Articles on XAF1
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Products associated with anti-XAF1 antibody
Pathways associated with anti-XAF1 antibody
Diseases associated with anti-XAF1 antibody
Organs/Tissues associated with anti-XAF1 antibody
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