NP_001010888
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,543 Da
NCBI Official Full Name
probable ribonuclease ZC3H12B
NCBI Official Synonym Full Names
zinc finger CCCH-type containing 12B
NCBI Protein Information
probable ribonuclease ZC3H12B; MCP-induced protein 2; zinc finger CCCH domain-containing protein 12B
UniProt Protein Name
Probable ribonuclease ZC3H12B
UniProt Synonym Protein Names
MCP-induced protein 2; Zinc finger CCCH domain-containing protein 12B
UniProt Synonym Gene Names
UniProt Entry Name
ZC12B_HUMAN
NCBI Summary for ZC3H12B
The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]
UniProt Comments for ZC3H12B
ZC3H12B: May function as RNase and regulate the levels of target RNA species (Potential). Belongs to the ZC3H12 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.-.-
Chromosomal Location of Human Ortholog: Xq12
Molecular Function: endonuclease activity; metal ion binding
Research Articles on ZC3H12B
1. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
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Diseases associated with anti-ZC3H12B antibody
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