NP_003444.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,809 Da
NCBI Official Full Name
zinc finger MYM-type protein 2
NCBI Official Synonym Full Names
zinc finger, MYM-type 2
NCBI Protein Information
zinc finger MYM-type protein 2; zinc finger protein 198; fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder
UniProt Protein Name
Zinc finger MYM-type protein 2
UniProt Synonym Protein Names
Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198
UniProt Synonym Gene Names
UniProt Entry Name
ZMYM2_HUMAN
NCBI Summary for ZMYM2
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Comments for ZMYM2
ZNF198: a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. The translocation between FGFR and ZNF198 (8;13)(p11;q12) is oncogenic, causing stem cell leukemia lymphoma syndrome (SCLL), a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The transforming activity of ZNF198-FGFR1 requires the proline-rich domains, but not the ZNF domains, of ZNF198.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 13q11-q12
Cellular Component: PML body; cytosol
Molecular Function: ubiquitin conjugating enzyme binding; zinc ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on ZMYM2
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Pathways associated with anti-ZMYM2 antibody
Diseases associated with anti-ZMYM2 antibody
Organs/Tissues associated with anti-ZMYM2 antibody
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