NP_663722.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
amyloid beta A4 protein-binding family B member 1 isoform b
NCBI Official Synonym Full Names
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NCBI Protein Information
amyloid beta A4 precursor protein-binding family B member 1; stat-like protein; adaptor protein FE65a2
UniProt Protein Name
Amyloid beta A4 precursor protein-binding family B member 1
UniProt Synonym Protein Names
Protein Fe65
UniProt Synonym Gene Names
UniProt Entry Name
APBB1_HUMAN
NCBI Summary for APBB1
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for APBB1
Fe65: adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity.
Protein type: Transcription regulation; Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: growth cone; lamellipodium; cytoplasm; plasma membrane; synapse; nuclear speck; nucleus
Molecular Function: protein binding; histone binding; beta-amyloid binding; chromatin binding; transcription factor binding
Biological Process: axon guidance; extracellular matrix organization and biogenesis; positive regulation of DNA repair; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; neuron migration; signal transduction; negative regulation of thymidylate synthase biosynthetic process; negative regulation of neuron differentiation; regulation of transcription, DNA-dependent; axonogenesis; double-strand break repair; visual learning; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; cell cycle arrest; response to DNA damage stimulus
Research Articles on APBB1
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Products associated with anti-APBB1 antibody
Pathways associated with anti-APBB1 antibody
Diseases associated with anti-APBB1 antibody
Organs/Tissues associated with anti-APBB1 antibody
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