NP_001184166.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
butyrophilin subfamily 2 member A2 isoform a
NCBI Official Synonym Full Names
butyrophilin, subfamily 2, member A2
NCBI Protein Information
butyrophilin subfamily 2 member A2; butyrophilin 2
UniProt Protein Name
Butyrophilin subfamily 2 member A2
UniProt Synonym Gene Names
UniProt Entry Name
BT2A2_HUMAN
NCBI Summary for BTN2A2
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
UniProt Comments for BTN2A2
BTN2A2: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: integral to membrane
Biological Process: negative regulation of activated T cell proliferation; negative regulation of cytokine secretion; negative regulation of cellular metabolic process
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Diseases associated with anti-BTN2A2 antibody
Organs/Tissues associated with anti-BTN2A2 antibody
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