EAX02560.1
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UniProt Related Accession #
NCBI Official Full Name
cholinergic receptor, nicotinic, alpha 10
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, alpha 10 (neuronal)
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-10; NACHR alpha-10; nicotinic acetylcholine receptor subunit alpha-10; cholinergic receptor, nicotinic, alpha polypeptide 10; acetylcholine receptor, nicotinic, alpha 10 (neuronal)
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-10
UniProt Synonym Protein Names
Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10
UniProt Synonym Gene Names
UniProt Entry Name
ACH10_HUMAN
UniProt Comments for CHRNA10
nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; membrane; axon; perikaryon; cell junction
Molecular Function: calcium channel activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding
Biological Process: inner ear morphogenesis; elevation of cytosolic calcium ion concentration; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell proliferation; synaptic transmission, cholinergic
Research Articles on CHRNA10
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Products associated with anti-CHRNA10 antibody
Pathways associated with anti-CHRNA10 antibody
Diseases associated with anti-CHRNA10 antibody
Organs/Tissues associated with anti-CHRNA10 antibody
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