Q6UVK1.2
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Chondroitin sulfate proteoglycan 4
NCBI Official Synonym Full Names
chondroitin sulfate proteoglycan 4
NCBI Official Synonym Symbols
NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG [Similar Products]
NCBI Protein Information
chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan NG2; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4 (melanoma-associated)
UniProt Protein Name
Chondroitin sulfate proteoglycan 4
UniProt Synonym Protein Names
Chondroitin sulfate proteoglycan NG2; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan
UniProt Synonym Gene Names
UniProt Entry Name
CSPG4_HUMAN
NCBI Summary for CSPG4
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
UniProt Comments for CSPG4
NG2: a transmembrane chondrotin sulfate proteoglycan expressed on several types of immature progenitor cells and human malignant melanoma cells. Plays a role in cell proliferation and motility of endothelial cells during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. May regulate MPP16-dependent degradation and invasion of type I collagen participating to melanoma cells invasion properties. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through Cdc42, ACK1 and P130Cas. May activate FAK and ERK signaling cascades. PKC-alpha-mediated NG2 phosphorylation may be a key step for initiating cell polarization and motility.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: lysosomal lumen; focal adhesion; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; extracellular region
Molecular Function: signal transducer activity; protein kinase binding
Biological Process: chondroitin sulfate metabolic process; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; activation of MAPK activity; carbohydrate metabolic process; tissue remodeling; chondroitin sulfate catabolic process; pathogenesis; angiogenesis; glial cell migration; transmembrane receptor protein tyrosine kinase signaling pathway; dermatan sulfate biosynthetic process
Research Articles on CSPG4
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Products associated with anti-CSPG4 antibody
Pathways associated with anti-CSPG4 antibody
Diseases associated with anti-CSPG4 antibody
Organs/Tissues associated with anti-CSPG4 antibody
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