AAI36281.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Glutamate receptor, metabotropic 1
NCBI Official Synonym Full Names
glutamate receptor, metabotropic 1
NCBI Official Synonym Symbols
MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85 [Similar Products]
NCBI Protein Information
metabotropic glutamate receptor 1; protein phosphatase 1, regulatory subunit 85
UniProt Protein Name
Metabotropic glutamate receptor 1
UniProt Synonym Gene Names
UniProt Entry Name
GRM1_HUMAN
NCBI Summary for GRM1
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt Comments for GRM1
mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3
Chromosomal Location of Human Ortholog: 6q24
Cellular Component: integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; nucleus
Molecular Function: G-protein coupled receptor activity; protein binding; glutamate receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; protein kinase C activation; metabotropic glutamate receptor signaling pathway; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain
Disease: Spinocerebellar Ataxia, Autosomal Recessive 13
Research Articles on GRM1
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Pathways associated with anti-GRM1 antibody
Diseases associated with anti-GRM1 antibody
Organs/Tissues associated with anti-GRM1 antibody
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